Methods

Patients

Patients aged between  20 and 80 years are recruited  at the  CHUM ALS Clinic.  No patient was under riluzole treatment.

MRS

Single-voxel MRS data were acquired at 1.5 T in the precentral gyrus (8 cc) and in the brainstem (3 cc) using the PRESS sequence with TE = 30 ms or 135 ms. Each patient is examined three times: before minocycline treatment, 3 weeks and 6 weeks after initiating the treatment. The NAA/Cr, Cho/Cr, mI/Cr and Glx/Cr ratios are calculated.