Preliminary Results
Conditions of acquisition for the
techniques of MRI and MRS were established according to the results
obtained with volunteers. For example, the figure below shows a
magnetic
resonance spectrum acquired in the liver of a healthy volunteer where
the calculation of the lipid/water ratio by the software LCModel shows
a relative percentage of 5,8%. The conditions of acquisition of the DWI
and the DEI are also optimized. The measurements repeated on the same
subject showed that the reproducibility of the technique was very
satisfactory. The following stage, that is to say the take of
measurements among subjects controls and patients having steatosis can
now begin.
MRS spectra of a
healthy volounteer showing the lipid to water peak area ratio. During
acquisition, the subject has to stop breathing for increasing the
signal quality. Moreover, the water signal has to be saturated because
of its over presence in the liver. Finally, the spectra is treated with
informatics to eliminate the noise that degrades the curve.
Communication :
RUEL, M., LEPANTO, L., BILODEAU, M. & BOULANGER,
Y. : Noninvasive quantitation of liver triglycerides in steatosis methods
using MR methods. International Society
for Magnetic Resonance in Medicine, Fifteenth Scientific Meeting and Exhibition,
Berlin, Germany, 2007.
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